Research & Development

Personal Care

Personal Care

Phynova is developing several active ingredients for use in the cosmetic market. 

PhynoRadiance™
PhynoRadiance™ is a plant extract with potent activity as an α-glucosidase inhibitor. α-Glucosidases are enzymes that play crucial roles in both the breakdown of carbohydrates in the gut and in the formation of the enzyme tyrosinase, which is vital in the skin for the formation and deposition of melanin pigment. Inhibition of tyrosinase formation may lead to reduced age-related melanin pigmentation and therefore resultant skin lightening.  Although melanin is indispensible for the absorption of free radicals generated in cells, and plays an important role in blocking various types of radiation (such as UV), the increased production and accumulation in the skin characterizes a large number of skin diseases, including acquired hyperpigmentation.  The use of inhibitors of melanogenesis as skin lighteners is well documented but many are of limited effectiveness, difficult to formulate, and may cause side effects after long term use. Recent attention has switched to the potential of natural products as cosmetics and PhynoRadiance’s™ action as a natural α-glucosidase inhibitor makes it an excellent candidate as a skin lightening agent.


Activity studies with PhynoRadiance™ have shown:

    • PhynoRadiance™ was evaluated in a 28-day human trial and the study concluded that it was well tolerated and significantly lightened the skin and reduced skin pigmentation.

    • Inhibition of cellular melanin formation in tests directly comparing PhynoRadiance™ with arbutin, kojic acid and magnesium ascorbyl phosphate (VC-PMG) showed superior activity with no cytotoxicity observed.

    • Tests carried out comparing PhynoRadiance™ directly with arbutin showed a different mechanism of action and that anti-melanogenesis activity was linked to the inhibition of early tyrosinase formation.

    • PhynoRadiance™ exhibits similar potency to the α-glucosidase inhibitor DNJ (a key constituent of PhynoRadiance™) despite having a low DNJ content– indicating that within PhynoRadiance™ DNJ is working in synergy with other active compounds to inhibit melanin formation.

 

PhynoRadiance™ clinical trial results

  Day 0 Day 28



Effect of PhynoRadiance™ on skin lightness
Effect of PhynoRadiance™ on skin colour






For more information please visit www.phynoradiance.com